Fem Balance

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Chang A, Kwak BY, Yi K, Kim JS, The effect of herbal extract (EstroG-100) on pre-, peri, and post menopausal women: a randomized double-blind placebo-cntrolled study. Phytother Res. 2012 Apr; 26(4): 510-6.



*Quick Summary: This randomized double blind study demonstrated the effectiveness of the patented herbal combination of Angelica gigas, Phlomis umbrosa and Cyanacum wilfordii for helping to relieve Menopausal symptoms.


“This clinical research study was designed to evaluate the efficacy of a new herbal product,EstroG-100, containing a mixture of standardized extracts of Cynanchum wilfordii, Phlomis umbrosa and Angelica gigas, on menopausal symptoms. This randomized double-blind, placebo-controlled trial was performed for 12 weeks with 64 pre-, peri- and postmenopausal White Hispanic, White non-Hispanic and African American women who were randomly allocated to either EstroG-100 group (n = 31) or the placebo group (n =  33). Primary end-points were the mean change in scores of the Kupperman menopause index (KMI) that evaluates 11 symptoms, and the mean change in scores of vaginal dryness. The mean KMI score was significantly reduced in the EstroG-100 group from 29.5 ± 7.4 at baseline to 11.3 ± 5.8 (p < 0.01) compared with change of the placebo group (29.2 ± 6.6 at baseline vs 23.7 ± 7.7 at week 12). The constituting symptoms of vasomotor, paresthesia, insomnia, nervousness, melancholia, vertigo, fatigue and rheumatic pain were significantly improved in the EstroG-100 group in comparison with the placebo group (p < 0.05). Statistically significant improvement in vaginal dryness in the EstroG-100 group was also observed compared with that of the placebo group (p < 0.05). In conclusion,EstroG-100 significantly improved the menopausal symptoms of pre-, peri- and post-menopausal women without weight gain or any serious side effects.” [1]


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